Delta Air Lines, a major American carrier, has a history of operating routes to Moscow, Russia, although the service has been subject to changes over time due to geopolitical and market dynamics. Delta first began flying to Moscow in the early 1990s following the dissolution of the Soviet Union when the country opened up to international carriers. The service was initially aimed at meeting the growing demand for business and leisure travel between the United States and Russia. Over the years, Delta maintained its Moscow route, often connecting key U.S. hubs such as New York’s John F. Kennedy International Airport to Moscow’s Sheremetyevo and later Domodedovo International Airports. The airline's presence in Moscow provided travelers with a reliable transatlantic option, contributing to strengthening business ties and tourism between the two nations.

However, Delta’s operations to Moscow have not been uninterrupted. The airline has occasionally suspended flights due to various challenges, including fluctuating passenger demand, economic factors, and political tensions. For example, during periods of strained U.S.-Russia relations, including after the annexation of Crimea in 2014 and the subsequent imposition of sanctions, airlines faced a decline in demand for flights between the two countries. Moreover, the COVID-19 pandemic further disrupted global air travel, leading to significant reductions in international routes, including Delta's flights to Moscow. In 2022, amid the escalation of the Russia-Ukraine conflict and the imposition of severe sanctions against Russia by Western nations, Delta announced the suspension of its codeshare agreement with Russian carrier Aeroflot and ceased its flights to Moscow. These developments were part of broader industry-wide measures in response to the geopolitical crisis.

While Delta has operated flights to Moscow in the past and played a role in facilitating U.S.-Russia travel, its current and future operations to the city depend on evolving political and economic conditions. Airlines generally assess the viability of routes based on passenger demand, profitability, and regulatory considerations, all of which have been influenced by the complexities of U.S.-Russia relations. Therefore, while Delta’s history with Moscow underscores its adaptability to market opportunities, the route’s reinstatement, if it occurs, will likely depend on significant improvements in the geopolitical climate and the normalization of relations between the two nations.